Primary Sclerosing Cholangitis: Therapeutic Options and Surveillance Management
نویسندگان
چکیده
Primary sclerosing cholangitis is a chronic immune-mediated liver disease. Though rare, it poses several clinical concerns for the managing physician. There are currently limited therapeutic options in the management of the condition and weak evidence base behind them. Endoscopic intervention is limited to those patients with obstructing stricture-related disease, and even liver transplantation has a risk of disease recurrence. Surveillance for inflammatory bowel disorders, metabolic bone disease, and malignancy is paramount when managing such patients. This article provides an overview of the condition with further focus on current therapeutic options and guidance on surveillance management.
منابع مشابه
Primary sclerosing cholangitis - a comprehensive review.
Primary sclerosing cholangitis (PSC) is a rare disorder characterised by multi-focal bile duct strictures and progressive liver disease. Inflammatory bowel disease is usually present and there is a high risk of cholangiocarcinoma and colorectal cancer. Most patients ultimately require liver transplantation, after which disease recurrence may occur. With limited therapeutic options and a lack of...
متن کاملChallenges of Cholangiocarcinoma Detection in Patients with Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC) is a chronic, cholestatic, idiopathic liver disease characterized by fibroobliterative inflammation of the hepatic bile ducts. In a clinically significant proportion of patients, PSC progresses to cirrhosis, end-stage liver disease, and in some cases, cholangiocarcinoma (CCA). The development of CCA in PSC is unpredictable, its surveillance and diagnosis com...
متن کاملImmunosuppressive Therapy in Immune-Mediated Liver Disease in the Non-Transplanted Patient
Autoimmune liver disease management goals are primarily slowing disease progression and symptomatic treatment. There are few options for curative medical management other than transplant for a spectrum of autoimmune liver disease that encompasses autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis as well as their overlap syndromes. These diseases are managed primari...
متن کاملThe challenges in primary sclerosing cholangitis--aetiopathogenesis, autoimmunity, management and malignancy.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease, characterized by progressive inflammation and fibrosis of the bile ducts, resulting in biliary cirrhosis and is associated with a high risk of cholangiocarcinoma. The majority of patients are young, male and have coexisting inflammatory bowel disease. PSC is found with a prevalence of 10/100,000 in Northern European po...
متن کاملImproving Symptoms of Primary Sclerosing Cholangitis by Iranian Traditional Medicine
Introduction: Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic disease that results from the inflammation and destruction of intra- and extra-hepatic bile ducts and fibrosis which can lead to cirrhosis. The purpose of this report is to provide the clinical experience of Iranian traditional medicine with the best therapeutic effect within the shortest time. <s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2016